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Closed Wed, Oct 7. Responses were due Wed, Oct 7 · 5:00 PM ET. This notice is kept for reference and no longer takes responses.

Request for proposalsFederal buyer

ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening

HEALTH AND HUMAN SERVICES, DEPARTMENT OF, District of Columbia · NATIONAL INSTITUTES OF HEALTH · ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
Verified 1 h agoAmended Oct 6
Responses dueWed, Oct 75:00 PM ET · District of Columbia timeClosed
PostedWed, Sep 167 amendments, last Oct 7
Solicitation no.ARPA-H-SOL-26-165SAM.gov
Set-asideNoneOpen to all firms
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What the agency is buying

by RFPFinder from the notice and attachments; the solicitation governs

ARPA-H seeks innovative solutions for a Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative to prove or disprove the effect of microgravity on tissue aging. Multiple awards are anticipated.

Scope

  • Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative
  • Multiple Other Transaction awards resulting from this announcement
CompetitionLikely competitive

1 signal behind this label (incumbent, repeat winner, short window, brand-name or sole-source language, prior sources sought). Pro shows them with sources.

From USAspending awards and the notice text, recomputed nightly (Oct 7). A signal, not a verdict.

How to get the bid documents

Documents · 20 items, 20 filesDownload all (zip)
Start here
  • Pricing · f0acc10b4dcb42babcd3c651e8ee1469.xlsxView
  • Latest amendment · ARPA-H-SOL-26-165_COSMOS_ISO_Amendment 02.pdfView
  • PDF
    ARPA-H-SOL-26-165_COSMOS_QA_Set_2_2026-09-25.pdf53 KB · 7 pages
    View
  • PDF
    ARPA-H-SOL-26-165_COSMOS_ISO_Amendment 02.pdf1.7 MB · 40 pages
    View
  • PDF
    ARPA-H-SOL-26-165_COSMOS_QA_Set_1_2026-09-21.pdf27 KB · 2 pages
    View
  • DOCX
    Attachment E_COSMOS Administrative and National Policy Requirements.docx95 KB
    View
  • DOCX
    ATTACHMENT A.1_Technical & Management Proposal Model (VOL I).docx55 KB
    View
  • XLSX
    Attachment D_COSMOS Cost Proposal Template.xlsx146 KB
    View
  • DOCX
    ATTACHMENT A.2_Task Description Document Model.docx42 KB
    View
  • DOCX
    ATTACHMENT B_COSMOS Eligibility and Conformance Certification Sheet.docx36 KB
    View
  • XLSX
    ATTACHMENT C COSMOS Schedule.xlsx20 KB
    View
  • XLSX
    ATTACHMENT A.3_COSMOS Milestone and Payment Table.xlsx22 KB
    View
  • DOCX
    0bcc046159444a71985b08eb41da892c.docx36 KB
    View
  • XLSX
    3bffd79ec8644ff5a478dc5e5a60e0c2.xlsx146 KB
    View
  • DOCX
    4249cfb685fc45908b02847b13094000.docx95 KB
    View
  • DOCX
    42c5c638fedb4caca948f380a393f560.docx42 KB
    View
  • PDF
    59336b7374004766a1e3414ebf00ec67.pdf1.7 MB · 40 pages
    View
  • XLSX
    bb7c5c3bce3a4ebf9842cedc745abade.xlsx20 KB
    View
  • PDF
    ced54e96495c4d40b3f4ad4fb5fdf3d2.pdf53 KB · 7 pages
    View
  • DOCX
    e1208b36c5354eb8a9205ef41b35730c.docx55 KB
    View
  • XLSX
    f0acc10b4dcb42babcd3c651e8ee1469.xlsx22 KB
    View
  • PDF
    fcefbbb411f64e4c8fb6e43618d66b50.pdf27 KB · 2 pages
    View
Open the original listing on SAM.gov

Details

Place of performance
Washington, District of Columbia
Buyer type
Federal
Notice type
Solicitation
Solicitation no.
ARPA-H-SOL-26-165
NAICS
NAICS 541714 (Research and Development in Biotechnology (except Nanobiotechnology)): 12 open RFPs
PSC
PSC AN13: 10 open RFPs
Local presence
Not required
Amendments
7, last Oct 7
Contact
COSMOS Team
Office
NATIONAL INSTITUTES OF HEALTH · ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
Email
COSMOS@ARPA-H.GOV

Not stated in the notice: estimated value, contract type, period of performance, evaluation criteria. Check the bid documents.

Contact details from the source notice. Contact the buyer only about this solicitation.

Key dates

Wed, Sep 16Posted
Not statedQuestions due
Wed, Oct 7 · 5:00 PM ETResponses due · closed
Amendment 1
Thu, Sep 17
Amendment 2
Mon, Sep 21
Amendment 3
Wed, Sep 23
Amendment 4
Fri, Sep 25
Amendment 5
Tue, Oct 6
Amendment 6
Wed, Oct 7 · The government procurement notice has been updated to include additional details about the COSMOS Initiative and its goals.
Amendment 7
Wed, Oct 7 · The government procurement notice has been updated to include additional details about the COSMOS Initiative and its goals.
Closed
Wed, Oct 7

Change log

verified Wed, Oct 7 · 5:00 PM ET
  1. Posted · SolicitationWed, Sep 16 · 11:17 AM ET
  2. Amendment · New version of the notice posted at the sourceThu, Sep 17 · 7:51 AM ET
  3. Amendment · New version of the notice posted at the sourceMon, Sep 21 · 3:06 PM ET
  4. Amendment · New version of the notice posted at the sourceWed, Sep 23 · 8:30 AM ET
  5. Amendment · New version of the notice posted at the sourceFri, Sep 25 · 8:37 AM ET
  6. Amendment · New version of the notice posted at the sourceTue, Oct 6 · 8:00 PM ET
  7. Amendment · The government procurement notice has been updated to include additional details about the COSMOS Initiative and its goals.Wed, Oct 7 · 12:31 AM ET
  8. Amendment · The government procurement notice has been updated to include additional details about the COSMOS Initiative and its goals.Wed, Oct 7 · 12:31 AM ET
  9. ClosedWed, Oct 7 · 5:00 PM ET

Change log starts Oct 5, 2026 (tracking began); earlier amendments at SAM.gov are being pulled in.

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Notice as published

ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) Innovative Solutions Opening

The Advanced Research Projects Agency for Health (ARPA-H) Comprehensive Organ System Modeling in Outer Space (COSMOS) Initiative aims to definitively prove or disprove if exposure to microgravity in Low Earth Orbit (LEO) truly accelerates tissue aging across brain, cardiac, uterine, and kidney tissue types and across several adult age brackets. Provided Tissue Aging Rate in Space (TARIS) exceeds Tissue Aging Rate on Earth (TAROE) at a rate that exceeds the on Earth breakeven cost for new drug R&D, COSMOS will create a first-in-class platform for fully autonomous, high-throughput drug screening in LEO that would be more cost effective and faster than new drug R&D on Earth. ARPA-H anticipates multiple Other Transaction awards resulting from this announcement.

Interested parties are invited to download and review the attached COSMOS Innovative Solutions Opening (ISO) ARPA-H-SOL-26-165

Similar National Institutes of Health awards · PSC AN13

USAspending.gov, last 36 months

8 awards matched · tier 2: National Institutes of Health + PSC AN13; nothing from this office. Most recent:

  • Sep 15, 2024KITWARE INCFY24 ARPA-H SBIR TOPIC H05 DIRECT-TO-PHASE II, "AI-ENHANCED COMPACT ULTRASOUND FOR AUTONOMOUS NEWBORN HEART MONITORING AND CONGENITAL DISEAS75N91024C00020 · DEFINITIVE CONTRACT · National Institutes of Health · ends Mar 30, 2028$3.5M
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Awards updated Tue, Oct 6, 2026 · 6:30 AM ET.

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