| Southeastern Equipment Company, Inc. | 17 | $2.4M | Department of the Army |
| Southeastern Food Distribution Inc | 4 | $3.6M | Agricultural Marketing Service |
| Southeastern Industrial Barlovento JV-2, LLC | 8 | $64M | Department of the Army |
| Southeastern Industrial Construction, LLC | 28 | $46M | Department of the Army |
| Southeastern Institute of Research, Inc. | 3 | $875K | City of Richmond |
| Southeastern Kentucky Rehabilitation Industries, Inc | 39 | $66M | Defense Logistics Agency |
| Southeastern Paper Group, LLC | 9 | $64M | Defense Commissary Agency |
| Southeastern Public Service Authority of Virginia | 3 | $2.8M | Department of the Navy |
| Southern Aire Contracting, Inc. | 25 | $54M | Department of the Navy |
| Southern Automotive Wholesalers, Inc | 298 | $6.1M | Defense Logistics Agency |
| Southern Belle LLC | 10 | $42K | City-Parish of Baton Rouge |
| Southern Building Co LLC | 4 | $13M | Department of Veterans Affairs |
| Southern California Edison Company | 18 | $6.4M | City of Los Angeles Controller |
| Southern California Gas Co | 16 | $41M | City of Los Angeles Controller |
| Southern California Marine Enterprises | 5 | $37K | Defense Logistics Agency |
| Southern California Pipe | 14 | $161K | City of Los Angeles Controller |
| Southern Careers Institute, Inc. | 21 | $2.2M | Federal Prison System / Bureau of Prisons |
| Southern Chemical Supply Inc | 6 | $2.0M | Department of the Navy |
| Southern College of Optometry | 3 | $155K | Department of the Navy |
| Southern Collision & Restoration LLC | 10 | $153K | Federal Acquisition Service |
| Southern Computer Warehouse, Inc. | 86 | $237K | Texas DIR |
| Southern Consolidated Holdings LLC | 17 | $9K | Department of the Navy |
| Southern Contracting, LLC | 10 | $93M | Department of the Army |
| Southern Counties Lubricants, LLC | 89 | $223K | City of Los Angeles Controller |
| Southern Counties Oil Co., A California Limited Partnership | 3 | $70K | Defense Logistics Agency |
| Southern Cross Aviation, LLC | 64 | $2.4M | Defense Logistics Agency |
| Southern Dredging Co Inc | 8 | $53M | Department of the Army |
| Southern Earth Sciences Inc | 20 | $581K | City-Parish of Baton Rouge |
| Southern Express International Inc | 68 | $24K | City of Los Angeles Controller |
| Southern Fasteners & Supply, LLC | 6 | $202K | Department of the Navy |
| Southern Federal, LLC | 5 | $4.8M | Department of the Army |
| Southern Foods Group, LLC | 14 | $8K | Defense Logistics Agency |
| Southern Foodservice Management Inc | 3 | $3.8M | Department of the Army |
| Southern Gear & Machine Inc | 10 | $185K | Defense Logistics Agency |
| Southern Illinois Waste Container, LLC | 3 | $130K | Federal Prison System / Bureau of Prisons |
| Southern Indiana Steel Inc | 21 | $1.8M | Department of the Navy |
| Southern Light LLC | 12 | $1.4M | Defense Information Systems Agency |
| Southern Management Inc | 12 | $23M | Department of the Air Force |
| Southern Maryland Towing Inc | 5 | $24K | Department of the Army |
| Southern Methodist University | 9 | $24M | Department of the Air Force |
| Southern Missouri Reentry, LLC | 3 | $4.9M | Federal Prison System / Bureau of Prisons |
| Southern Oregon Sanitation LLC | 6 | $1.6M | Department of Veterans Affairs |
| Southern Perfection Fabrication Holdings, Inc. | 3 | $34K | Defense Logistics Agency |
| Southern Petroleum Laboratories Inc | 4 | $92K | TCEQ |
| Southern Pipe & Supply | 18 | $27K | City-Parish of Baton Rouge |
| Southern Planet Solutions LLC | 5 | $161K | Department of the Army |
| Southern Police Equipment Company, Inc. | 10 | $299K | Department of Energy |
| Southern Power Systems Services Inc | 3 | $16K | Department of Veterans Affairs |
| Southern Premier Foodservice LLC | 4 | $8.9M | Department of the Army |
| Southern Prosthetic Supply, Inc. | 7 | $1.3M | Department of the Army |
| Southern Queens Park Association, Inc. | 9 | $50M | New York City |
| Southern Research Institute | 19 | $22M | National Institutes of Health |
| Southern Sanitation Inc | 3 | $255K | Federal Prison System / Bureau of Prisons |
| Southern Shores Engineering LLC | 8 | $95K | City-Parish of Baton Rouge |
| Southern Sourcing Solutions, LLC | 3 | $0 | TxDOT |
| Southern States LLC | 9 | $6.8M | NY State Authorities |
| Southern Taproot LLC | 3 | $383K | Forest Service |
| Southern Technologies Corp. | 9 | $1.3M | MTA Procurements |
| Southern Tire Mart, LLC | 217 | $2.8M | City of Mesquite |
| Southlake Landscape & Maintenance | 71 | $908K | City of Mesquite |
| Southland Dodge Chrysler | 9 | $482K | City-Parish of Baton Rouge |
| Southland Industries | 7 | $113M | Department of the Army |
| Southland Printing Co Inc | 4 | $5.5M | MTA Procurements |
| Southpoint Consulting, Inc. | 3 | $37M | Federal Acquisition Service |
| Southside Market, LLC. | 3 | $375K | City of Chicago |
| Southside United Housing Development Fund Corporation | 4 | $3.7M | New York City |
| Southwest Brooklyn Industrial Development Corp | 4 | $680K | New York City |
| Southwest Calibration Labs, Inc. | 3 | $54K | Department of Veterans Affairs |
| Southwest Carpenters Trusts | 17 | $513K | City of Los Angeles Controller |
| Southwest Collective | 3 | $109K | City of Chicago |
| Southwest Concrete Paving Co | 4 | $59M | Department of the Navy |
| Southwest Construction & Property Management | 18 | $10M | National Park Service |
| Southwest Contracting & Associates LLC | 6 | $956K | Forest Service |
| Southwest Distribution Inc | 15 | $708K | Executive Office of the President |
| Southwest Flooring Solutions Inc | 21 | $109K | Department of the Air Force |
| Southwest Hazard Control Inc | 14 | $761K | Department of Veterans Affairs |
| Southwest Healthcare Staffing You LLC | 23 | $12M | Indian Health Service |
| Southwest Lift & Equipment Inc | 11 | $6K | City of Los Angeles Controller |
| Southwest Louisiana Veterans Home | 4 | $612K | Department of Veterans Affairs |
| Southwest Material Handling, Inc. | 5 | $84K | Department of the Navy |
| Southwest Microwave Inc | 5 | $304K | NY State Authorities |
| Southwest Mobile Storage Inc | 9 | $2K | City of Los Angeles Controller |
| Southwest Nursery & Supply | 9 | $12K | City of Mesquite |
| Southwest Organizing Project | 8 | $1.9M | City of Chicago |
| Southwest Research Institute | 184 | $858M | Department of the Air Force |
| Southwest Shipyard LP | 4 | $47M | Department of the Army |
| Southwest Solutions Group Inc | 34 | $2.5M | Department of the Air Force |
| Southwest Valley Constructors Co | 9 | $2.7B | Department of the Army |
| Southwest Water Design, L.l.c. | 7 | $1.0M | Bureau of Reclamation |
| Southwest Wear Parts Co Inc | 7 | $8K | City of Los Angeles Controller |
| Southwestern Bell Telephone Company | 83 | $2.1M | City of Mesquite |
| Southwestern Community College District | 4 | $223K | Department of the Navy |
| Southwestern Industries, Inc | 10 | $532K | Department of the Navy |
| Southwestern Security Services, Inc. | 3 | $1.5M | Office of Procurement Operations |
| Southwind Construction Corp. | 8 | $47M | Department of the Army |
| Southwind Construction Services, LLC | 12 | $80M | Department of the Army |
| Southwind Enterprises Incorporated | 5 | $47K | Defense Logistics Agency |
| Southwire Company | 5 | $313K | MTA Procurements |
| Southwood Building Systems Inc | 5 | $24M | City of Richmond |
| Southworth-Milton, Inc. | 34 | $2.1M | Department of Veterans Affairs |