| Sony Biotechnology Inc. | 6 | $1.3M | National Institutes of Health |
| Sophia Genetics, Inc. | 3 | $3.1M | Defense Health Agency |
| Sophion Bioscience Inc | 3 | $492K | Department of Veterans Affairs |
| Sora Power Inc. | 22 | $927K | Defense Logistics Agency |
| Sorenson Installations LLC | 11 | $1.0M | Department of the Air Force |
| Sori E&C Co.,ltd | 45 | $52M | Department of the Army |
| Sorinex Exercise Equipment Inc | 7 | $545K | Department of the Army |
| Sorrento Lumber Co Inc | 4 | $102K | City-Parish of Baton Rouge |
| Sos International LLC | 25 | $247M | Department of the Army |
| Sos Locksmith Corp | 3 | $73K | MTA Procurements |
| S.o.s. Portables Corporation | 4 | $74K | Department of the Air Force |
| Sos Solutions, LLC. | 11 | $756K | Department of the Army |
| Sosic Painting & Remodeling LLC | 3 | $120K | U.S. Coast Guard |
| Sotaris LLP | 5 | $650K | Department of Veterans Affairs |
| Soterix Medical, Inc. | 4 | $1.2M | Department of Veterans Affairs |
| Sotx Facility Services LLC | 3 | $856K | Department of the Army |
| Soulful Creations Inc | 15 | $164K | Department of the Army |
| Sound Com Corporation | 3 | $350K | Department of Veterans Affairs |
| Sound Communications, Inc. | 3 | $44M | New York City |
| Sound Pro NY, Inc. | 5 | $313K | NY State Authorities |
| Sound Productions, LLC. | 4 | $251K | Department of the Navy |
| Sound Testing, Inc | 4 | $17K | U.S. Coast Guard |
| Sound Tree Studio LLC | 4 | $3.9M | MTA Procurements |
| Source Code LLC | 11 | $951K | Department of the Navy |
| The Source Group, Inc. | 5 | $125M | Defense Logistics Agency |
| Source IT Technologies LLC | 8 | $1.6M | MTA Procurements |
| Source IT Technologies LLC Kara Homan | 14 | $1.5M | NY State Authorities |
| Source Media LLC | 7 | $122K | Oregon State Treasury |
| Source of Future Technology Inc. | 9 | $112M | MTA Procurements |
| Source One Construction, LLC | 4 | $516K | Federal Aviation Administration |
| Source One Spares LLC | 36 | $128M | Department of the Navy |
| Sourceamerica | 73 | $360M | Department of the Army |
| Sourcecorp BPS Inc. | 3 | $7.8M | New York City |
| Sourcelinq LLC | 24 | $1.8M | Department of the Army |
| SourceMatch Inc. | 6 | $94K | Texas DIR |
| Sourceone, Inc | 5 | $66M | MTA Procurements |
| South Alabama Contracting LLC | 7 | $14M | Federal Prison System / Bureau of Prisons |
| South Alabama Regional Airport Authority | 27 | $13K | Defense Logistics Agency |
| South Asian Youth Action SAYA Inc | 3 | $41M | New York City |
| South Bay Edc Inc | 15 | $68M | Department of the Navy |
| South Bay Ford | 11 | $5K | City of Los Angeles Controller |
| South Bay Sand Blasting and Tank Cleaning, Inc. | 17 | $696K | Department of the Navy |
| South Bay Wire and Cable Company, LLC | 4 | $512K | Department of the Navy |
| South Central Manufacturing Corp | 18 | $969K | Defense Logistics Agency |
| South Chicago Dance Theatre | 3 | $115K | City of Chicago |
| South Coast A Q M D | 3 | $823 | City of Los Angeles Controller |
| South Coast Air Quality Management District | 5 | $161K | Department of Veterans Affairs |
| South Coast Aqmd | 15 | $12K | City of Los Angeles Controller |
| South County Artificial Limb Company | 6 | $151K | Department of Veterans Affairs |
| South County Industrial Emergency Counci | 9 | $1.7M | San Francisco |
| South Dade Air Conditioning & Refrigeration Inc | 185 | $161M | Public Buildings Service |
| South Dakota Department of Health | 8 | $787K | Indian Health Service |
| South Dakota Department of Military and Veterans Affairs | 4 | $1K | Department of Veterans Affairs |
| South Dakota School of Mines & Technology | 7 | $23M | Department of the Army |
| South Dakota Urban Indian Health, Inc. (Sduih) | 5 | $3.6M | Indian Health Service |
| South-East Asia Center | 5 | $406K | City of Chicago |
| South-East Asia Center|cleaned-Up | 5 | $1.3M | City of Chicago |
| South East Machine LLC | 5 | $32K | Defense Logistics Agency |
| South Eastern General Contracting, Inc. | 8 | $8.4M | Department of the Army |
| South Eastern Road Treatment, Inc | 5 | $313K | Forest Service |
| South Florida Aviation Investments, Inc. | 8 | $9K | Defense Logistics Agency |
| South Florida Clinical Treatment Centers Inc | 43 | $21M | Federal Prison System / Bureau of Prisons |
| South Jersey Heat and Cool Limited Liability Company | 3 | $263K | Department of the Army |
| South National for Logistics | 3 | $65M | Defense Logistics Agency |
| South Park Stakeholders Group | 3 | $64K | City of Los Angeles Controller |
| South Puget Sound Comm College | 5 | $5 | State of Washington |
| South Puget Sound Community College | 5 | $5 | State of Washington |
| South Shore Chamber Community Development Corporation | 5 | $4.4M | City of Chicago |
| South Shore Drill Team & Performing Arts Ensemble | 3 | $147K | City of Chicago |
| South Shore Drill Team & Performing Arts Ensemble|cleaned-Up | 5 | $594K | City of Chicago |
| South Shore Hospital.corp | 4 | $608K | City of Chicago |
| South Side Community Arts Center | 3 | $72K | City of Chicago |
| South Side Help Center 01 | 9 | $1.4M | City of Chicago |
| South Texas Lighthouse for the Blind Foundation | 96 | $35M | Department of the Air Force |
| South Town Refrigeration, LLC | 11 | $1.2M | Department of Veterans Affairs |
| South Western Communications Inc | 4 | $926K | Department of Veterans Affairs |
| Southco & Assoc., Inc. | 4 | $0 | Defense Logistics Agency |
| Southco Services LLC | 51 | $2.6M | Department of Veterans Affairs |
| Southcoast Welding & Manufacturing, LLC. | 86 | $106M | Department of the Navy |
| Southeast Aerospace, Inc. | 7 | $1.3M | Defense Logistics Agency |
| Southeast Asian Community Center | 6 | $486K | San Francisco |
| Southeast Asian Development Center | 6 | $9.9M | San Francisco |
| Southeast Bronx Neighborhood Centers Inc | 6 | $28M | New York City |
| Southeast Cherokee Construction, Inc. | 17 | $72M | Department of the Army |
| Southeast Chicago Chamber | 4 | $137K | City of Chicago |
| Southeast Chicago Commision | 6 | $419K | City of Chicago |
| Southeast Connections, LLC | 4 | $49M | City of Richmond |
| Southeast Construction Prods | 10 | $9K | City of Los Angeles Controller |
| Southeast Constructors Inc | 3 | $3.6M | Department of the Army |
| Southeast Extinguisher Service, Inc. | 10 | $42K | U.S. Coast Guard |
| Southeast Geospatial, JV LLC | 5 | $13M | Department of the Navy |
| Southeast Louisiana Veterans Home | 5 | $760K | Department of Veterans Affairs |
| Southeast Mechanical Corp | 7 | $6.5M | NY State Authorities |
| Southeast Power Systems of Orlando Inc | 3 | $1K | Defense Logistics Agency |
| Southeast Safety Solutions LLC | 176 | $100K | City-Parish of Baton Rouge |
| Southeast Uniform Company | 5 | $595K | Department of the Navy |
| Southeastern Archaeological Research, LLC | 19 | $11M | Department of the Army |
| Southeastern Biomedical Associates Incorporated | 5 | $660K | Department of the Army |
| Southeastern Computer Consultants, Inc. | 8 | $278M | Department of the Navy |
| Southeastern Engineering Sales, Inc. | 3 | $90K | Department of the Navy |