66--dPCR Instrument

NOTICE OF INTENT This is a notice of intent to solicit from a single source. The US Geological Survey (USGS) intends to award a purchase order to Qiagen LLC in Germantown, MD, for a digital PCR (dPC) instrument with the following Salient Characteristics: - Delivers precise and multiplexed quantification results for genetic studies - Integrates the standard dPCR workflow of partitioning, thermocycling, and imaging in one platform - Capable of detecting up to 5 fluorescent dyes or more - 1 Thermocycler on board - High-Order Multiplexing & Sensitivity: Capable of measuring up to 5 targets simultaneously, enhancing detection of rare mutations, copy number variations (CNV), and gene expression with high precision. - Rapid Workflow: The system reduces the typical digital PCR workflow to roughly 2 hours - Reduced Sample/Reagent Use: Can analyze multiple targets in a single reaction - High Throughput & Automation: It supports 96-well and 24-well plate formats, with the capacity to handle up to 480 samples per 8-hour shift, and supports automation for sample preparation. - Processes 1 or more plates at a time - Flexible sample throughput - Fully integrated system - Compatible with computer using Microsoft Windows 10 or 11 64-bit version, with x64 processor with 4 physical cores and 2.5GHz, main memory of 16GB Ram or more, hard disk space of minimum 500GB, and graphics interface of 1920x1080 - Does not have integrated GPS Award will be made in accordance with Federal Acquisition Regulation (FAR) procedures at FAR Part 12 entitled, Acquisition of Commercial Items. Qiagen LLC is, to the knowledge of the USGS, the only source who can provide this proprietary equipment that is compatible with existing systems.

This notice of intent is not a request for competitive quotes. However, all responsible parties may submit a quotation which shall be considered by the agency. No solicitation will be issued.

A determination not to compete this action based upon responses received is in the sole discretion of the Government. The NAICS code 334516, Analytical Laboratory Instrument Manufacturing, and PSC 6640, Laboratory Equipment and Supplies, apply to this announcement. Responses or inquiries shall only be accepted through electronic mail addressed to [email on the source notice] and must be uploaded and received in their entirety no later than 09/08/2026 at 0900 PDT.

Responses submitted by hardcopy or any web portal shall not be accepted or considered.