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Closes in 42 hoursResponses due Fri, Oct 9 at 12:00 PM ET · about 42 hours left
Request for proposalsFederal buyer

Selective Harnessing of Intrinsic Neuroplasticity Engineering (SHINE)

DEPT OF DEFENSE, Virginia · DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) · DEF ADVANCED RESEARCH PROJECTS AGCY
Verified 18 h agoAmended Aug 28
Responses dueFri, Oct 912:00 PM ET · Virginia timeabout 42 hours left
PostedFri, Aug 282 amendments, last Sep 28
Solicitation no.DARPA-PA-25-07-06SAM.gov
Set-asideNoneOpen to all firms
Estimated value$2.0Mfrom notice
Open at source to respondHelp me respondCompliance checklist
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What the agency is buying

by RFPFinder from the notice and attachments; the solicitation governs

The Defense Advanced Research Projects Agency (DARPA) is issuing a Disruption Opportunity (DO) for innovative basic or applied research concepts in targeted neuroplasticity. The total award value is limited to $2,000,000 per award.

Scope

  • SHINE seeks technologies capable of establishing circuit-selective neuroplasticity through innovative approaches that spatially localize plasticity-inducing
  • Proposed solutions may integrate advances in molecular engineering, precision delivery, biomaterials, neuromodulation, synthetic biology, cellular engineering,
TDP access mandatory before bidSubmission: physicalDays to respond: 2
CompetitionLikely competitive

1 signal behind this label (incumbent, repeat winner, short window, brand-name or sole-source language, prior sources sought). Pro shows them with sources.

From USAspending awards and the notice text, recomputed nightly (Oct 7). A signal, not a verdict.

How to get the bid documents

  1. Download the 4 stored documents below; 2 more open at the source
  2. Check the submission requirements in the compliance checklist
  3. Submit by physical before 12:00 PM ET on Oct 9
Documents · 6 items, 6 filesDownload all (zip)
Start here
  • Pricing · SHINE_Streamlined_Cost_Buildup_Workbook_Amendment_1.xlsxView
  • Latest amendment · SHINE_Amendment_1_Summary_of_Changes.docxView
  • PDF
    DARPA-PA-25-07-06-Amendment-01.pdf196 KB · 11 pages
    View
  • DOCX
    SHINE_Amendment_1_Summary_of_Changes.docx26 KB
    View
  • XLSX
    SHINE_Streamlined_Cost_Buildup_Workbook_Amendment_1.xlsx36 KB
    View
  • PDF
    DARPA-PA-25-07-06.pdf194 KB · 11 pages
    View
  • DOC
    https://sam.gov/opp/af580f92ade44eb997a3c47ba74888f5/viewexternal link
    Source
  • XLSX
    Streamlined_Cost_Buildup_Workbook.xlsx29 KBat source
    Source
Open the original listing on SAM.gov

Details

Place of performance
ARLINGTON, Virginia
Buyer type
Federal
Notice type
Solicitation
Solicitation no.
DARPA-PA-25-07-06
NAICS
NAICS 541715 (Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)): 123 open RFPs
PSC
PSC AC11: 11 open RFPs
Period of performance
18-month base + 6 one-year options from notice
Contract type
Other Transaction (OT) for Prototype Agreement from notice
Estimated value
$2.0M from notice
Local presence
Not required
Amendments
2, last Sep 28
Contact
BAA Coordinator
Office
DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) · DEF ADVANCED RESEARCH PROJECTS AGCY
Email
SHINE@darpa.mil

Contact details from the source notice. Contact the buyer only about this solicitation.

Key dates

Fri, Aug 28Posted
Not statedQuestions due
Fri, Oct 9 · 12:00 PM ETResponses due · about 42 hours left Under 14 days
Amendment 1
Thu, Sep 3
Amendment 2
Mon, Sep 28

Change log

verified Wed, Oct 7 · 12:30 AM ET
  1. Posted · SolicitationFri, Aug 28 · 12:27 PM ET
  2. Amendment · New version of the notice posted at the sourceThu, Sep 3 · 7:17 AM ET
  3. Amendment · New version of the notice posted at the sourceMon, Sep 28 · 12:47 PM ET
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Notice as published

Selective Harnessing of Intrinsic Neuroplasticity Engineering (SHINE)

The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) is issuing a Disruption Opportunity (DO), inviting submissions of innovative basic or applied research concepts in the technical domain of targeted neuroplasticity. This DO is issued under the Program Announcement for Disruptioneering, DARPA-PA-25-07 Amendment 1.

All awards will be made in the form of an Other Transaction (OT) for Prototype Agreement. The total award value for this DO is limited to $2,000,000 per award. This total award value includes Government funding and performer cost share if required or proposed.

What this office paid before

USAspending.gov, last 36 months

25 awards matched · tier 1: this contracting office (HR0011) + PSC AC11. Most recent:

  • Jul 5, 2026THE JOHNS HOPKINS UNIVERSITY APPLIED PHYSICS LABORATORY LLCCOMPOSITIONAL LEARNING-AND-REASONING FOR ARTIFICIAL INTELLIGENCE COMPLEX SYSTEMS ENGINEERING (CLARA) EFFORT UNDER THE JOHNS HOPKINS UNIVERSIHR001126FE045 · DELIVERY ORDER · Defense Advanced Research Projects Agency · ends Nov 6, 2027$1.2M
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Awards updated Tue, Oct 6, 2026 · 4:43 AM ET.

This contracting office

22 other open notices from this office · buys mostly Other, Consulting

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