What the agency is buying

by RFPFinder from the notice and attachments; the solicitation governs

The Advanced Research Projects Agency for Health (ARPA-H) is seeking proposals for the Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic program. Multiple awards are anticipated, with offers evaluated based on scientific and technical merit, proposer capabilities, relevance to the ARPA-H mission, and cost/price.

Scope

Develop methods for generating region-specific precursor brain tissue.
Demonstrate proof-of-concept for surgical engraftment in preclinical models.

Proposal validity ≥ 120 daysQ&A closedSubmission: portalDays to respond: 142

CompetitionLikely competitive

1 signal behind this label (incumbent, repeat winner, short window, brand-name or sole-source language, prior sources sought). Pro shows them with sources.

From USAspending awards and the notice text, recomputed nightly (Oct 7). A signal, not a verdict.

How to get the bid documents

Download the 3 stored documents below; 5 more open at the source
Check the submission requirements in the compliance checklist
Submit by portal before 5:00 PM ET on Feb 26, 2027

Documents · 8 items, 8 filesDownload all (zip)

PDF
BRAINS_ISO_ARPA-H-SOL-26-148 Amendment 1.pdf305 KB · 41 pages
View
ZIP
OT Bundle of Attachments.zip1.3 MB
View
PDF
BRAINS ISO ARPA-H-ISO-26-148.pdf484 KB · 41 pages
View
DOC
BRAINS Exploratory Topicexternal link
Source
DOC
BRAINS Q&A / Sidebar Registrationexternal link
Source
DOC
Solution Summary Submission Portalexternal link
Source
DOC
Full Proposal Submission Portalexternal link
Source
DOC
BRAINS FAQsexternal link
Source

Open the original listing on SAM.gov

Details

Place of performance: Washington, District of Columbia
Buyer type: Federal
Notice type: Solicitation
Solicitation no.: ARPA-H-SOL-26-148
NAICS: NAICS 541715 (Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)): 123 open RFPs
PSC: PSC AN13: 10 open RFPs
Period of performance: 18 months from attachment p.6
Contract type: Other Transactions from attachment p.4
Estimated value: $1.0M from attachment p.9
Local presence: Not required
Amendments: 3, last Oct 7
Contact: BRAINS Team
Office: NATIONAL INSTITUTES OF HEALTH · ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
Email: BRAINS@ARPA-H.GOV

Contact details from the source notice. Contact the buyer only about this solicitation, and note the question deadline has passed.

Key dates

Mon, Jun 8, 2026Posted

Jun 22, 2026Q&A closed

Jun 9, 2026Pre-bid held

Fri, Feb 26, 2027 · 5:00 PM ETResponses due · 142 days left

Amendment 1: Mon, Jun 8, 2026
Amendment 2: Wed, Jul 1, 2026
Amendment 3: Wed, Oct 7, 2026 · The government has added details about the funding opportunity, including the BRAINS Exploratory Topic program, award types, and submission deadlines.

Change log

verified Wed, Oct 7 · 12:30 AM ET

Posted · SolicitationMon, Jun 8 · 11:00 AM ET
Amendment · New version of the notice posted at the sourceMon, Jun 8 · 11:33 AM ET
Amendment · New version of the notice posted at the sourceWed, Jul 1 · 11:31 PM ET
Updated · description text changedWed, Oct 7 · 12:34 AM ET
Amendment · The government has added details about the funding opportunity, including the BRAINS Exploratory Topic program, award types, and submission deadlines.Wed, Oct 7 · 12:34 AM ET

Change log starts Oct 5, 2026 (tracking began); earlier amendments at SAM.gov are being pulled in.

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Notice as published

Brain Repair of Any Injured Neural Structure (BRAINS)

The Advanced Research Projects Agency for Health (ARPA-H) posts this funding opportunity in support of the Brain Repair of Any Injured Neural Structure (BRAINS) Exploratory Topic program. ARPA-H anticipates multiple awards with Other Transaction award types resulting from this announcement. Interested parties are invited to review the Innovative Solutions Opening (ISO) ARPA-H-SOL-26-148.

Parties interested in submitting a proposal in response to the ARPA-H BRAINS ISO are required (mandatory) to submit a solution summary. No awards will be made, or funding provided as a result of a solution summary submission.

Intake Group 1: Solution Summaries Due: July 9th, 2026, 5:00 PM Full Proposals Due: August 6th, 2026, 5:00PM Intake Group 2: Solution Summaries Due: January 7th, 2027, 5:00 PM Full Proposals Due: February 6th, 2027, 5:00PM

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Sep 15, 2024KITWARE INCFY24 ARPA-H SBIR TOPIC H05 DIRECT-TO-PHASE II, "AI-ENHANCED COMPACT ULTRASOUND FOR AUTONOMOUS NEWBORN HEART MONITORING AND CONGENITAL DISEAS75N91024C00020 · DEFINITIVE CONTRACT · National Institutes of Health · ends Mar 30, 2028$3.5M

Pro

Pro shows every award with the recipient, amount, period and a link to the award record, plus a CSV export. $39/mo.

Awards updated Tue, Oct 6, 2026 · 6:55 AM ET.

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Listing collected from SAM.gov. Always confirm requirements in the original solicitation before you bid.